منابع مشابه
Ethical issues in genetic linkage studies of psychiatric disorders.
Recent advances in molecular genetics have radically altered the prospects for determining the role of heredity in the transmission of major psychiatric disorders. Identification of the actual gene(s) involved, elucidation of their structure, and determination of their products are the steps which theoretically follow successful demonstration of linkage (Gurling, 1985; Baron & Rainer, 1988). Co...
متن کاملModern molecular genetic approaches to psychiatric disease.
Major advances in molecular genetics over the last 15 years have made it possible to identify the genes responsible for human diseases using purely genetic approaches that do not require knowledge about disease pathophysiology. Many successes have been achieved for single gene disorders and methods are being adapted and refined for complex diseases. The main strategies include linkage and assoc...
متن کاملCan linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument.
Recent advances in DNA technology have accelerated the process of locating genes on the human chromosome map or genome, have increased the scope and precision of the information available for genetic counselling, and have revitalized the outlook for research into human genetics as a whole. As the mapping of the human chromosomes proceeds apace using simple markers blood groups, protein polymorp...
متن کاملFamilial Scheuermann disease: a genetic and linkage study.
Scheuermann juvenile kyphosis or Scheuermann disease is the most frequent cause of kyphosis in adolescence. However, the natural history and genetic basis is still unknown. Reports of identical radiological changes in monozygotic twins, sib recurrence, and transmission over three generations suggest underlying heritability. In this study, 12 probands were referred to us. Upon radiological exami...
متن کاملEvidence for genetic linkage of Alzheimer's disease to chromosome 10q.
Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Abeta, the principal component of beta-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses r...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/344298a0